Biology of Aggression

Unchecked aggression and violence take a significant toll on society. Even if we manage to avoid being the direct victim of a violent act, the effects of aggression and violence reach us all: We hear about the mauling of a woman by an aggressive dog, our children are bullied at school, or we deal with impulsive violence while commuting to work or attending a sporting event. Reflecting psychology in general, the dominant roles of learning and environmental influences - both social and nonsocial - have traditionally been prominent in discussions of the etiology of human aggression. Biological factors have not been considered sufficiently important to investigate in the search for ways of dealing with human aggression or violence. With recent advances in pharmacology and genetic manipulation techniques, however, new interest has developed in the biological mechanisms of both non-human and human aggression. Although aggression is certainly a complex social behavior with multiple causes, molecular biological factors should not be overlooked, as they may well lead to interventions that prevent excess aggressive behaviors.The primary goal of this book is to summarize and synthesize recent advances in the biological study of aggression. As most aggressive encounters among human and non-human animals represent a male proclivity, the research in this book describes and discusses studies using the most appropriate murine model: testosterone-dependent offensive inter-male aggression, which is typically measured in resident-intruder or isolation-induced aggression tests. The research also emphasizes various molecules that have been linked to aggression tests. The research also emphasizes various molecules that have been linked to aggression by the latest gene-targeting and pharmacological techniques. Although the evidence continues to point to androgens and serotonin (5-HT) as major hormonal and neurotransmitter factors in aggressive behavior, recent work with GABA, dopamine, vasopressin, and other factors, such as nitric oxide, has revealed significant interactions with the neural circuitry underlying aggression. This book is organized according to levels of analysis. The first section examines the genetic contributions to aggression in species ranging from crustaceans to humans.The section summarizes the involvement of various neurotransmitters and neuromodulators in aggressive behavior. The third section summarizes the influence of hormones on aggression, primarily in humans. All chapters emphasize future directions for research on aggression and reveal important domains that have received comparatively less attention in this literature. Considered together, these chapters provide up-to-date coverage of the biology of aggression by some of the leading authorities currently working in this field. "Biology of Aggression" will direct future research to continue the recent advances in the pharmacological and genetic approaches to understanding aggression and violence. It promises to be a valuable resource for professional and student researchers in neuroscience, psychiatry, cognitive and developmental psychology, behavioral biology, and veterinary medicine.

Contents: SECTION 1: GENES; Chapter 1 Genetic Aspects of Aggression in Nonhuman Animals; Chapter 2 Human Quantitative Genetics of Aggression; Chapter 3 Crustacean Models of Aggression; SECTION 2: NEUROTRANSMITTERS; Chapter 4 Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates; Chapter 5 Monoamines, GABA, Glutamate, and Aggression; Chapter 6 Nitric Oxide and Aggression; Chapter 7 Neuroplasticity and Agression: An Interaction Between Vasopressin and Serotonin; SECTION 3: HORMONES; Chapter 8 Contexts and Ethology of Vertebrate Aggression: Implications for the Evolution of Hormone Behavior Interactions; Chapter 9 Androgens and Aggression; Chapter 10 The Role of Estrogen Receptors in the Regulation of Aggressive Behaviors; Chapter 11 Maternal Aggression; Chapter 12 Stress and Aggressive Behaviors; STRESS 4: DEVELOPMENT; Chapter 13 Conditioned Defeat; Chapter 14 Development of Aggression; Chapter 15 Neurobiology of Aggression in Children; SECTION 5: PHARMACOLOGY AND PSYCHOPHYSIOLOGY; Chapter 16 Drugs of Abuse and Aggression; Chapter 17 Psychopharmacology of Human Aggression: Laboratory and Clinical Studies; Chapter 18 Psychophysiology of Human Antisocial Behavior